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. 2021 Sep 23;22(19):10240. doi: 10.3390/ijms221910240

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PMN treatment reduces the toxicity of 6-OHDA exposure and α-synuclein overexpression in the SH-SY5Y cell line. Cells were treated with 0.1, 0.2, 0.5, 1, 2, or 4 μM PMN for 24 h (SH-SY5Y group), followed by 6-OHDA exposure for 18 h (6-OHDA-treated SH-SY5Y group), or α-synuclein-overexpressing cells were treated with PMN for 24 h (α-synuclein-overexpressing SH-SY5Y group), and the cell survival rate was determined by MTT assay. ^# Indicates a significant difference between the 6-OHDA-exposed group or α–synuclein-overexpressing group and the control group (^## p < 0.01, ^### p < 0.001). * Indicates a significant difference between the PMN-treated group and the PMN-untreated group (* p < 0.05, ** p < 0.01).