TABLE 1.

Bacteremia factors can be shared across multiple species or conserved in only one species, and many factors have been confirmed in only one phase of bacteremia^a

Category	Fitness gene(s)	Species	Subfunction	Initial site	Intraperitoneal	TVI	Reference(s)
Metabolism	speAB, gltB, gdhA	P. mirabilis	Amino acid			X	44
	pqqL, c1220	E. coli	Amino acid			X	50
	ddc	A. baumannii	Amino acid			X	45
	glnA	P. mirabilis	Amino acid; carbohydrate; energy			X	44
	nanA	E. coli	Carbohydrate			X	49
	mtlD	C. freundii	Carbohydrate			X	43
	pfkA	C. freundii, S. marcescens	Carbohydrate			X	42, 43
	mgtB, pgm	S. marcescens	Carbohydrate; energy			X	42
	gltA	K. pneumoniae	Carbohydrate	X	X		53
	pntB	A. baumannii	Cofactor and vitamin			X	45
	cysE	C. freundii	Energy			X	43
	tonB	E. coli, K. pneumoniae	Iron transport		X (K. pneumoniae)	X	49, 99
	hma, chuA	E. coli	Iron transport			X	49
	feoB	A. baumannii	Iron transport			X	45
Cellular maintenance	pilVS, fim, pap	E. coli	Adherence	X		X	49, 50
	pic, vat	E. coli	Autotransporter serine protease			X	50
	pgaABCD	E. coli	Biofilm formation	X		X	50
	ksl	E. coli	Capsule production			X	49
	wzx	S. marcescens	Capsule production			X	42
	sufl	C. freundii	Cell growth			X	43
	UMH9_0939	S. marcescens	Membrane synthesis			X	42
	mltB	A. baumannii	Membrane synthesis	X		X	51
	dam	K. pneumoniae	Replication and repair	X	X		104
	ruvA	C. freundii	Replication and repair			X	43
Environmental response	sapABCDF, oppA	E. coli	Membrane transport			X	50
	tatC	C. freundii, P. mirabilis	Membrane transport			X	43, 44
	potB	P. mirabilis	Membrane transport			X	44
	ompK36	K. pneumoniae	Membrane transport		X		103
	fepA	A. baumannii	Signal transduction			X	45
	ntrB	P. mirabilis	Signal transduction			X	44
	exoU, exoS, exoT, exlA	P. aeruginosa	Toxins	X			55, 120, 122
Unclassified	yddB	E. coli	Uncharacterized			X	50
	UMH9_0544	S. marcescens	Uncharacterized			X	42

^aTVI, tail vein injection.