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. 2021 Oct 13;15:765205. doi: 10.3389/fncel.2021.765205

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Copyright © 2021 Bi, Fang, You, He and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The activation mechanism of M1 microglia after ICH. In ICH acute phase, M1 microglia are activated on account of the blood composition and neuron primary damage. Meanwhile, microglia up-express corresponding receptors for activation.