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. 2021 Oct 13;15:765205. doi: 10.3389/fncel.2021.765205

Table 4.

Clinical researches on microglial regulation for ICH therapy.

Drugs Continent No. of patients Outcomes Efficacy References
minocycline North America 10 NIHSS, mRS, mortality NO Chang et al. (2017)
North America 8 mRS NO Fouda et al. (2017)
deferoxamine mesylate Asian 47 hematoma volume, edema YES Yu et al. (2017)
fingolimod Asian 23 hematoma volume, NIHSS YES Fu et al. (2014)
Asian 11 edema YES Li et al. (2015)
statins Europe 29 NIHSS, mortality YES Tapia-Pérez et al. (2013)
North America 38 hematoma volume; edema YES Witsch et al. (2019)

NIHSS, National Institute of Health stroke scale; mRS, modified Rankin Scale.