Fig. 3.

Model for long-range synaptic complex. The long-range synaptic complex (PDB: 7LT3) (Chen et al., 2021a) was generated using ChimeraX 1.1.1 (Pettersen et al., 2021). The N-HEAT domain is shown in light blue, the M-HEAT in green and the kinase domain in red. The FAT domain is in pink and the FATC in tan. dsDNA is shown in dark orange. The Ku heterodimer, XLF and XRCC4-Lig4 are shown in grey. The structure on the right is rotated by 90° to reveal the relative positions of the kinase domains (red) and circular cradles (green) in the opposing DNA-PKcs molecules. The location of the ATM-dependent phosphorylation site S3205 is shown in yellow