Fig. 6.

Signal propagation pathway from the ECD to the TMD in the human $\mathrm{\alpha }$4$\mathrm{\beta }$2 nAChR from D-NEMD simulations. Average C$\mathrm{\alpha }$-positional deviation at times 0, 0.05, 0.5, 1, and 5 ns following nicotine annihilation. The structural response of the receptor was extracted using the Kubo–Onsager relation (Eq. 4). The time evolution of the response of the receptor is mapped onto the average structure for the system without nicotine using the colour scheme in the scale. This image was adapted from reference [37]