Fig. 7.

General mechanism for signal transduction in nAChRs revealed by D-NEMD simulations. Comparison between inter-domain signal propagation pathways in the human $\mathrm{\alpha }7$ and human $\mathrm{\alpha }4\mathrm{\beta }2$ nAChRs. Note that although there are differences in the apparent rates of propagation between the two receptors, the sequence of conformational changes associated with the initial steps of signal transmission is the same, i.e., the structural elements involved are the same. This image was adapted from references [37] and [34]