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. 2021 May 13;7(2):160–174. doi: 10.1007/s40883-021-00208-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — RNA sequencing analysis in the mucosa palate after local delivery of FTY720 in oral wound injury. ONF was created in 11 mice and scaffolds with or without FTY720 were added at the site of the injury for a local drug delivery. From a total of 11 animals, 6 animals were treated with blank scaffold (with no drug added) and 5 were treated with scaffolds loaded with FTY720. RNA sequencing analysis were performed in the mucosa of the hard palate. The sequencing revealed 669 differential expressed genes (DE). The yellow circle indicated that 623 genes were upregulated by FTY720, and the blue circle is the 46 genes downregulated by FTY720. The volcano plot revealed many more genes are significantly upregulated than downregulated by FTY720 considering p adjusted q≤0.05