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. 2021 Sep 15;6(5):e00564-21. doi: 10.1128/mSphere.00564-21

FIG 3.

FIG 3

CYS-3 binds the promoters and regulates the expression of genes involved in amino acid and sulfur metabolism. (A) Heat map of the expression level of the 172 genes that were at least 2-fold differentially expressed between wild-type and cys-3− cells exposed to sulfur starvation. The upper heat map contains genes activated by CYS-3. The lower heat map contains genes repressed by CYS-3. Purple bars indicate genes whose promoters were bound by CYS-3 using DAP-seq. (B) Distribution of genes in KEGG categories (50) and adjusted P values reflecting the significance of enrichment of genes assigned to a given KEGG category, as calculated using FungiFun 2.2.8 (49), of the 172 genes that were at least 2-fold differentially expressed between wild-type and cys-3− cells exposed to sulfur starvation. (C) Distribution of genes in KEGG categories (50) and adjusted P values reflecting the significance of enrichment of genes assigned to a given KEGG category, as calculated using FungiFun 2.2.8 (49), of the 64 genes whose promoters were bound by CYS-3 and that were at least 2-fold differentially expressed between wild-type and cys-3− cells exposed to sulfur starvation.