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. 2021 Oct 27;7(44):eabh0050. doi: 10.1126/sciadv.abh0050

Fig. 8. Pan-glial immunity induction affects longevity and climbing ability.

Fig. 8.

(A) Longevity of flies with pan-glial immunity induction compared to control flies (repo-Gal4, UAS-CD8Cherry versus repo-Gal4 UAS-PGRP-LE). The viability is markedly reduced (n = 200 females; P = 3.75 × 10−92). (B) Same genotypes as in (A). The climbing ability of 7-day-old flies is markedly reduced upon immunity induction (****P < 0.0001). (C to F) Two-day-old pupae with immunity induction stained for macrophages using [hml∆dsRed] and subsequent anti-dsRed staining, and either anti-HRP (green) (C and D) to label neuronal membranes or anti-Brp (green) (E and F) to label synapses. Note that macrophages harbor vesicles containing neuronal membrane material [arrowheads in (D′), (F′), and (F″)]. Scale bars, 100 μm (C and E) and 5 μm (D and F).