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. 2021 Oct 27;7(44):eabh2007. doi: 10.1126/sciadv.abh2007

Fig. 8. Circadian desynchrony and metabolic dysfunction.

Fig. 8.

External LD cycles force the synchronization of the internal SCN-DKO clock, but the external/internal T-cycle dissonance increases feeding and sensitivity to DIO. This circadian dissonance can be corrected by adjusting the external LD cycle to the endogenous free-running period in mice lacking REV-ERBs in the SCN (SCN-DKO mice).