FIG 1.

Age-related variation in the taxonomic composition of the human gut resistome. Principal-coordinate analysis of Bray-Curtis dissimilarities between the family (a) and genus-level (d) profiles of the gut resistome of young adults (Y), younger elderly individuals (E), centenarians (C), and semisupercentenarians (S). Significant separation was found at both phylogenetic levels (P = 0.0015 and 0.001, respectively; permutation test with pseudo-F ratios). Pie charts of the 25 most abundant families (b) and genera (e) for each group (Y, E, C, and S). Boxplots showing the relative abundance distribution of significantly differentially represented families (c) and genera (f) between age groups (Wilcoxon test, Bonferroni corrected P value). ***, P ≤ 0.0001; **, P ≤ 0.001; *, P ≤ 0.05.