Table 2. Association between clinico-histopathological features and protein expressions among women seeking care at Kilimanjaro Christian Medical Centre (n = 145).
| Variables | N = 145 | p16 protein expression | p-valuea | TOP2A protein expression | p-valuea | |||
|---|---|---|---|---|---|---|---|---|
| Low | High | Low | Moderate | High | ||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||
| Age (years) | 0.813 b | 0.256 b | ||||||
| <30 | 5 (3.4) | 2 (40.0) | 3 (60.0) | 3 (60.0) | 1 (20.0) | 1 (20.0) | ||
| 30–39 | 21 (14.5) | 7 (33.3) | 14 (66.7) | 11 (52.4) | 3 (14.2) | 7 (33.3) | ||
| 40–49 | 48 (33.1) | 16 (33.3) | 32 (66.7) | 20 (41.7) | 12 (25.0) | 16 (33.3) | ||
| 50–59 | 34 (23.4) | 8 (23.5) | 26 (76.5) | 11 (32.4) | 7 (20.6) | 16 (47.1) | ||
| 60–69 | 25 (17.2) | 7 (28.0) | 18 (72.0) | 7 (28.0) | 2 (8.0) | 16 (64.0) | ||
| >70 | 12 (8.3) | 2 (16.7) | 10 (83.3) | 3 (25.0) | 4 (33.3) | 5 (41.7) | ||
| Histopathological class | <0.001 | <0.001 | ||||||
| Benign | 33 (22.8) | 33 (100) | 0 (0) | 30 (90.9) | 2 (6.1) | 1 (3.0) | ||
| Precancerous | 11 (7.6) | 2 (18.2) | 9 (81.8) | 8 (72.7) | 2 (18.2) | 1 (9.1) | ||
| Cancerous | 95 (65.5) | 1 (1.1) | 94 (98.9) | 11 (11.6) | 25 (26.3) | 59 (62.1) | ||
| Non-definitive diagnosis | 6 (4.1) | 6 (100) | 0 (0) | 6 (100) | 0 (0) | 0 (0) | ||
| Histopathological subtype | ||||||||
| Benign cervical lesion | 1.000 | 0.479 b | ||||||
| Cervicitis | 15 (10.3) | 15 (100) | 0 (0) | 13 (86.7) | 1 (6.7) | 1 (6.7) | ||
| Endocervical polyps | 15 (10.3) | 15 (100) | 0 (0) | 14 (93.3) | 1 (6.7) | 0 (0) | ||
| Others | 3 (2.1) | 3 (100) | 0 (0) | 2 (66.7) | 1 (33.3) | 0 (0) | ||
| Precancerous cervical lesion | 1.000 b | 0.241 b | ||||||
| CIN-1 | 7 (4.8) | 2 (28.6) | 5 (71.4) | 6 (85.7) | 1 (14.3) | 0 (0) | ||
| CIN-2 | 1 (0.7) | 0 (0) | 1 (100) | 0 (0) | 0 (0) | 1 (100) | ||
| CIN-3 | 3 (2.1) | 0 (0) | 3 (100) | 2 (66.7) | 1 (33.3) | 0 (0) | ||
| Cancerous cervical lesion | 0.122 b | 0.584 b | ||||||
| Squamous cell carcinoma | 83 (57.2) | 0 (0) | 83 (100) | 10 (12.0) | 23 (27.7) | 50 (60.2) | ||
| Adenocarcinoma | 6 (4.1) | 1 (16.7) | 5 (83.3) | 1 (16.7) | 0 (0) | 5 (83.3) | ||
| Others | 6 (4.1) | 0 (0) | 6 (100) | 0 (0) | 2 (33.3) | 4 (66.7) | ||
| Non-definitive diagnosis | 6 (4.1) | 6 (100) | 0 (0) | 6 (100) | 0 (0) | 0 (0) | ||
aFisher’s exact test
b simulated p-value
CIN cervical intraepithelial lesion