Table 4. Diagnostic values of p16 and TOP2A immunohistochemistry in differentiating cancerous cervical lesions from benign and precancerous cervical lesions among women seeking cervical cancer care at Kilimanjaro Christian Medical Centre (n = 139).
| Methods | p16 | TOP2Aa | p16 plus TOP2Aa |
|---|---|---|---|
| % (95% CI) | % (95% CI) | % (95% CI) | |
| Sensitivity | 97.2 (85.5–99.9) | 77.6 (63.4–88.2) | 85.9 (76.6–92.5) |
| Specificity | 91.3 (84.1–95.9) | 93.3 (86.1–97.5) | 92.2 (87.5–95.6) |
| Accuracy | 92.8 (87.2–96.5) | 87.8 (81.1–92.7) | 90.3 (86.2–93.5) |
CI confidence intervals
a modified expression levels (low: moderate + high)