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. 2021 Oct 27;16(10):e0258833. doi: 10.1371/journal.pone.0258833

Fig 2. The mitochondrial redox state during machine perfusion of ischemic livers.

Fig 2

a) Representative RR spectrum of a liver with a low 3RMR (blue) and a high 3RMR (red). Peaks for distinguishing oxidized and reduced mitochondria are identified in the figure with black lines. These peaks represent unique vibrational modes of the porphyrin ring in the mitochondrial cytochromes and result from vibrations of the individual bonds of the molecule as shown. [17]. b) 3RMR of 24 and 72 hours cold ischemic liver during 3 hours of machine perfusion, blue and red respectively. c) Data distribution of the 3RMR at 120 minutes of perfusion. d) Data distribution of the 3RMR at 180 minutes of perfusion. Stars denote statistical significance (two-way repeated measures ANOVA, followed the Sidak’s post-hoc test): *0.01 < p < 0.05; **0.001 < p < 0.01; ***0.0001 < p < 0.001; ****p < 0.0001. Boxes: Median with interquartile range. Whiskers: Min max.