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. Author manuscript; available in PMC: 2021 Dec 15.
Published in final edited form as: Sci Immunol. 2021 Jun 15;6(60):eaba8426. doi: 10.1126/sciimmunol.aba8426

Fig. 1. Combining local ablative IR and RA inhibited tumor growth and induced antitumor memory.

Fig. 1.

(A) Scheme of the treatment schedule. Daily administration of RA by gavage at 400 μg/dose.

(B) Growth curve of MC38 tumors treated with oil, RA, 15 Gy+oil or 15 Gy plus RA.

(C) Percentage of tumor bearing mice over time post indicated treatment. Animals were pooled from three separate experiments.

(D) Survival curve of mice in (C). Data from three independent experiments were pooled.

(E) Tumor growth curve in cured (MC38) and naive mice which were re-challenged with 5 X106 MC38 or 1X106 LLC cells respectively.

(F) Growth curve of B16 tumor in mice treated with oil, RA, 15Gy + oil or 15Gy and RA combined.

(G) Growth cure of kidney cancer Renca tumor treated with oil, RA, 15Gy + oil or 15Gy and RA combined.

Representative data are shown from two or three experiments conducted with 5-10 mice per group, except for C and D. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001. N.S., not significant.