Features and properties of odevixibat

Alternative names	Bylvay; A4250
Class	Acetamides, butyric acids, hepatoprotectants, small molecules, sulfones, thiazepines
Mechanism of action	Sodium-bile acid cotransporter inhibitors
Route of administration	Oral
Pharmacodynamics	Selectively and reversibly inhibits the ileal BA transporter; reduces BA levels in serum/plasma by reducing BA reuptake in the distal ileum and increasing colon clearance of BAs
Pharmacokinetics	Minimal absorption and metabolism; eliminated mainly via the faeces; half-life ≈ 2.5 h
Most frequent adverse events	Diarrhoea, increased hepatic enzymes (including alanine transferase and aspartate transferase), increased blood bilirubin, increased international normalized ratio
ATC codes
WHO ATC code	A05A-X05 (odevixibat)
EphMRA ATC code	A5A (bile therapy and cholagogues)
Chemical name	(S)-2-((R)-2-(2-((3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,2,5]thiadiazepin-8-yl)oxy)acetamido)-2-(4-hydroxyphenyl)acetamido)butanoic acid

BA bile acid