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. 2021 Oct 27;16(10):e0259211. doi: 10.1371/journal.pone.0259211

Fig 1. The mRNA expression of the fibrotic marker in the mice skin with lesion.

Fig 1

mRNA levels of Collagen 1α, CTGF, αSMA, TGF-β, HAS-1, HAS-2, HAS-2, HAS-3, Hyal-1, and Hyal-2 were evaluated in the skin lesion after Gd injection. Mice with severe skin lesions in the gadodiamide group showed high fibrotic markers similar to those found in NSF skin lesions (A-E, G, I-J). In mice with mild lesions, HAS-1 and HAS-3 were not increased while other mRNA levels were (F, H). In the gadopentetate group, collagen 1α and TGF-β mRNA expression were increased, while CTGF expression was decreased (A-C). Other mRNA expression in the gadopentetate group were similar to the control group. mRNA level in control mice were assigned as values of 1. ns = not significant, *p < 0.05, **p < 0.01.