Table 3 .

In vitro screening studies and proposed repurposing drugs

Target	Drug Libraries	Proposed candidate	Reference
3CLpro	~10,000 compounds of approved or clinical used drugs and natural products from commercial libraries e.g. Target Mol, Selleck, Shanghai Institute for Advanced Immunochemical Studies	Ebselen, Disulfiram, Tideglusib, Carmofur Shikonin	Jin et al., 2020 [17]
	18 protease inhibitors including HCV or HIV proteases	Boceprevir, GC-376	Fu et al., 2020 [15]
	Various flavonoids	Baicalin, Herbacetin, Pectolinarin	Jo S. et al., 2020 [20]
	Dompe “Safe-In-Man” proprietary collection (containing 607 drug candidates), EU-OPENSCREEN, DrugRepurposingHub)	Thioguanosine, MG-132, Myricetin	Kuzikov et al., 2021 [19]
PL pro	5,576 compounds (3,727 approved drugs and late-stage clinical drug candidates)	No candidate found	Klemm T et al., 2020 [71]
RdRp	~5000 Commercial libraries (Sigma, Selleck, Enzo, Tocris, Calbiochem, Symansis)	GSK-650394, C-646, BH3I-1, Suramin, Cefsulodin	Bertolin et al., 2021 [72]
Nsp13	~5000 Commercial libraries (Sigma, Selleck, Enzo, Tocris, Calbiochem, Symansis)	FPA124, Suramin	Zeng et al., 2021 [73]
Nsp14 (N7-MTase)	~5000 Commercial libraries (Sigma, Selleck, Enzo, Tocris, Calbiochem, Symansis)	Trifluperidol, PF-03882845, Inauhzin, Lomeguatrib	Basu et al., 2021 [75]
Nsp14 (ExoN)	~5000 Commercial libraries (Sigma, Selleck, Enzo, Tocris, Calbiochem, Symansis)	Patulin, Aurintricarboxylic acid	Canal et al., 2021 [74]
Nsp15	~5000 Commercial libraries (Sigma, Selleck, Enzo, Tocris, Calbiochem, Symansis)	NSC95397	Canal et al., 2021 [29]
	ReFRAME drug repurposing library	Exebryl-1	Choi R et al., 2021 [76]