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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Neuropharmacology. 2021 Oct 2;200:108819. doi: 10.1016/j.neuropharm.2021.108819

Figure 1. Sex differences in cocaine intake and lever responding.

Figure 1.

(A) Active- and inactive-lever responses and cocaine infusions (mean ± SEM) obtained by male (n = 57) and female (n = 88) rats in experiments 1–4 during daily 2-h cocaine-self-administration and extinction training sessions. (B) Active- and inactive-lever responses during the 15-min cocaine-memory reactivation (MR) session (before intra-BLA treatment in males, n = 57, and females, n = 88) and upon first re-exposure to the extinction (EXT) and cocaine-paired (COC) contexts (after intra-BLA vehicle treatment in males (n = 24) and females (n = 36). Symbols: Double daggers indicate difference from subsequent training sessions, ‡ ANOVA time main effect collapsed across sex, ‡time simple-main effect in a sex, Tukey’s test. Silcrows indicate difference from males, §ANOVA sex main effect collapsed across time, §sex simple-main effect during a session, Tukey’s test, or sex effect during the MR session, t-test. Pound sign indicates difference from the extinction context, #ANOVA context main effect collapsed across sex. All ps < 0.05.