Table 2. Surgical data of patients.
| Variables | PDS (n=175) | Early IDS (n=224) | DDS (n=150) | p-value | |
|---|---|---|---|---|---|
| PCI | 11.5 (2–33) | 10 (0–39) | 7 (0–31) | <0.001 | |
| Missing | 3 | 1 | 2 | ||
| PCI | <0.001 | ||||
| PCI ≤10 | 76 (44.2) | 112 (50.2) | 99 (66.9) | ||
| PCI >10 | 96 (55.8) | 111 (49.8) | 49 (33.1) | ||
| Missing | 3 | 1 | 2 | ||
| Surgical procedures | |||||
| Hysterectomy | 167 (95.4) | 203 (90.6) | 121 (80.7) | <0.001 | |
| Unilateral or bilateral salpingoophorectomy | 164 (93.7) | 210 (93.8) | 128 (85.3) | 0.007 | |
| Pelvic lymphadenectomy | 158 (90.3) | 205 (91.5) | 132 (88.0) | 0.533 | |
| Aortic lymphadenectomy | 158 (90.3) | 201 (89.7) | 129 (86.0) | 0.412 | |
| Infragastric omentectomy | 173 (98.9) | 222 (99.1) | 145 (96.7) | 0.212 | |
| Small bowel resection | 20 (11.4) | 14 (6.3) | 10 (6.7) | 0.130 | |
| Large bowel resection | 96 (54.9) | 81 (36.2) | 48 (32.0) | <0.001 | |
| If large bowel resection, rectosigmoid resection (n=225) | 86 (89.6) | 73 (90.1) | 45 (93.8) | 0.798 | |
| Multiple bowel resection | 19 (10.9) | 19 (8.5) | 10 (6.7) | 0.405 | |
| Appendectomy | 93 (53.1) | 111 (49.6) | 74 (49.3) | 0.724 | |
| Right diaphragm stripping | 108 (61.7) | 150 (67.0) | 69 (46.0) | <0.001 | |
| Left diaphragm stripping | 56 (32.0) | 78 (34.8) | 29 (19.3) | 0.004 | |
| If diaphragm stripping, diaphragm resection (n=330) | 31 (28.7) | 26 (17.1) | 15 (21.4) | 0.083 | |
| Atypical hepatic resection | 4 (2.3) | 6 (2.7) | 5 (3.3) | 0.895 | |
| Cholecystectomy | 20 (11.4) | 19 (8.5) | 6 (4.0) | 0.051 | |
| Celiac lymph node resection | 24 (13.7) | 29 (12.9) | 12 (8.0) | 0.226 | |
| Splenectomy | 43 (24.6) | 53 (23.7) | 31 (20.7) | 0.687 | |
| Distal pancreatectomy | 6 (3.4) | 14 (6.3) | 11 (7.3) | 0.277 | |
| Partial gastrectomy | 5 (2.9) | 4 (1.8) | 2 (1.3) | 0.689 | |
| Extended peritonectomy | 89 (50.9) | 117 (52.2) | 50 (33.3) | <0.001 | |
| Glissonectomy | 15 (9.5) | 16 (8.3) | 15 (12.7) | 0.447 | |
| Mesentery or bowel vaporisation | 39 (22.3) | 59 (26.3) | 27 (18.0) | 0.166 | |
| Partial abdominal wall resection | 15 (8.6) | 53 (23.7) | 32 (21.3) | <0.001 | |
| Partial cystectomy or ureteral resection | 4 (2.3) | 2 (0.9) | 2 (1.3) | 0.509 | |
| Cardiophrenic lymph node resection | 1 (0.6) | 3 (1.3) | 6 (4.0) | 0.085 | |
| Inguinal lymph node resection | 4 (2.3) | 7 (3.1) | 2 (1.3) | 0.562 | |
| Axillary lymph node resection | 0 (0) | 1 (0.4) | 1 (0.7) | 0.739 | |
| CC-score | 0.567 | ||||
| CC-0 | 157 (89.7) | 195 (87.1) | 129 (86.0) | ||
| CC-1 | 18 (10.3) | 29 (12.9) | 21 (14.0) | ||
| Aletti score | 0.006 | ||||
| <8 | 80 (45.7) | 125 (55.8) | 95 (63.3) | ||
| ≥8 | 95 (54.3) | 99 (44.2) | 55 (36.7) | ||
| HIPEC | 0.001 | ||||
| No | 174 (99.4) | 223 (99.6) | 142 (94.7) | ||
| Yes | 1 (0.6) | 1 (0.4) | 8 (5.3) | ||
| IP chemotherapy | <0.001 | ||||
| No | 156 (89.1) | 224 (100) | 150 (100) | ||
| Yes | 19 (10.9) | 0 (0) | 0 (0) | ||
| Bevacizumab | <0.001 | ||||
| No | 143 (81.7) | 164 (73.2) | 135 (90.0) | ||
| Yes | 32 (18.3) | 60 (26.8) | 15 (10.0) | ||
Values are presented as median (range) or number of patients (%). Bold-faced p-values indicate statistical significance.
CC-score, Completeness of Cytoreduction score; DDS, delayed debulking surgery; Early IDS, early interval debulking surgery; Extended peritonectomy, peritonectomy of more than three abdominal regions; HIPEC, hyperthermic intraperitoneal chemotherapy; IP, intraperitoneal; PCI, peritoneal cancer index; PDS, primary debulking surgery; PH, porta hepatis; Partial abdominal wall resection, partial resection of anterior abdominal wall sheath, omphalectomy or port site resection.