Fig. 2.

Cross-sectional association between age-adjusted DNAm GrimAge and cognitive, neuroimaging and physical traits in the LBC1936. Cognitive: An accelerated DNAm GrimAge was negatively associated with the general factor of cognitive ability, digit symbol coding, symbol search and matrix reasoning tasks. DNAm GrimAge was also associated with an increased mean four choice reaction time. Neuroimaging: Age-adjusted DNAm GrimAge was negatively associated with the ratios of white matter volume, brain volume and grey matter volume to intracranial volume, and positively associated with the ratio of volume of white matter hyperintensities to intracranial volume. Physical: An accelerated DNAm GrimAge was negatively associated with four measures of lung function: forced expiratory volume in 1 s, forced vital capacity, forced expiratory ratio and peak expiratory flow, as well as levels of iron, low-density lipoprotein cholesterol and total cholesterol. Age-adjusted DNAm GrimAge was positively associated with weight, levels of creatinine, body mass index as well as levels of C-reactive protein and interleukin-6. Horizontal lines indiciate 95% confidence intervals. BMI body mass index, CRP C-reactive protein, FCRT four choice reaction time, FER forced expiratory ratio, FEV forced expiratory volume, FVC forced vital capacity, GM grey matter, ICV intracranial volume, IL6 interleukin-6, LDL low-density lipoprotein, PEF peak expiratory flow, WM white matter, WHM white matter hyperintensities