. 2021 Aug 7;35(11):3073–3077. doi: 10.1038/s41375-021-01377-0

Table 1.

Predictive co-variates.

Immune model
Ref	Favourable	Unfavourable
14	NK like T-cells	NK-cells
13	NI	PD-1⁺CD8⁺ T-cells, CD28⁻CD57⁺CD8⁺ T-cells
22	Resting mast cells, CD8⁺ T-cells, M2 macrophages, Follicular helper T-cells	Activated NK-cells, Naïve B-cells
23	CTLA4⁻LAG3⁻ T-helper cells	M1 polarised macrophages, FOXP3⁺ helper T-cells, Tregs
15	NI	Eomes⁺ T-bet^low CD8⁺ T-cells
16	NI	CD4⁺ CD25⁺ CD127^low Treg
17	NI	ICOS⁺ Tregs
20	NI	PD-1, PD-L1, PD-L2, Co-expression of PD-1/CTLA-4, Co-expression of PD-L2/CTLA-4
21	NI	PVR, PVRL2
Metabolic model
32	Citrate	Lactate, 2-Oxoglutarate, Pyruvate, 2-Hydroxyglutarate, Glycerol-3-phosphate
33	Lysine, Methionine	NI
36	CYP2E1, HAAO, ITPKA, PAFAH1B2	ALDH2, DNMT3B, ENPP2, PHGDH, PSAT1
35	NI	PLA2G4A, HMOX2, AK1, SMPD3