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. 2020 Jan 20;26(8):4265–4276. doi: 10.1038/s41380-020-0645-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a This network is associated with “developmental disorder, hereditary disorder, and metabolic disease” (score 42, 15 differential metabolites). b This network is associated with “small molecule biochemistry, increased levels of creatinine, and cell signaling” (score 13, six differential metabolites). Differential metabolites highlighted in red represent increased levels, whereas metabolites highlighted in green represent decreased levels when compared with controls.