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. 2021 Mar 10;35(11):3304–3308. doi: 10.1038/s41375-021-01200-w

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© The Author(s) 2021, corrected publication 2022

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Fig. 2 — For all assays, the heatmap summarizes the activity of each variant relative to wild-type RUNX1 in HEK293T and HEL assays. In addition, the functional and ACMG/MM-VCEP classes [5] are given. Color codes are shown below. wt wild type, na not applicable, VUS variant of uncertain significance.