Figure 11.

Tau fibrillation (AT8 labeling) in aged marmoset (12–15 years). In early aged marmoset (12 years), mild AT8 labeling is observed in stellate cell layer II islands (a) and deeper layer V (b) in entorhinal cortex. The labeling pattern is diffuse and visualized in the cell soma and the proximal segment along apical dendrites. With more advanced age in marmosets (15 years), more fibrillated AT8 labeling is observed aggregating in entorhinal cortex layer II (c) and layer V (d). Mild tau fibrillation is visualized in pyramidal neurons in hippocampus CA3 (e) and CA1 (f) subfields, and dlPFC layer III (g) in aged marmoset. Scale bars, 25 µm