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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Cell Biochem Biophys. 2021 Jun 27;79(3):561–573. doi: 10.1007/s12013-021-01014-8

Fig. 3.

Fig. 3

Hyperoxia (HO) reduced the expression of TIE-2 and ANG-1. Western blot analysis of mouse lung tissue subjected to HO showed decreased expression of Tie2 at RNA (A) and TIE-2 at protein levels (B) in WT mice. Immunohistochemistry (IHC) of lung tissue showed HO induced decrease in expression of TIE-2 in S1pr1+/+ mice which recovered in S1pr1+/− mice (C, D). IHC showed a decreased expression of ANG-1 in the HO exposed S1pr1+/+ mice which was rescued in the S1pr1+/− mice exposed to HO (E, F). The statistical analysis was carried out using ANOVA where ** indicate p < 0.01, ***p < 0.001, ****p < 0.0001, n = 5–8/group