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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Cell Biochem Biophys. 2021 Jun 27;79(3):561–573. doi: 10.1007/s12013-021-01014-8

Fig. 4.

Fig. 4

Hyperoxia (HO) exposure reduced the expression of VEGF and blood vessel count. HO exposure resulted in reduced VEGF in lung tissue of S1pr1+/+ mice as shown by immunohistochemistry (A, B). This reduction was ameliorated in S1pr1+/− mice which showed higher expression of VEGF. HO was accompanied by a significant reduction in the number of order-1 arterioles in the WT mice which was improved in the S1pr+/− mice (C). The statistical analysis was carried out using ANOVA where *** indicate p < 0.001, n = 5–8/group