Table 4:
Biomarkers Comparison
| Derivation Cohort | Validation Cohort | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Severe AP (n=4) | Moderately Severe (n=6) | Mild AP (n=36) | Controls (n=20) | P-value* | Severe AP (n=4) | Moderately Severe (n=2) | Mild AP (n=19) | Controls (n=20) | P-value* | |
|
CRP <0.4 0.4-2.5 >2.5 |
1/2 (50%) 1/2 (50%) 0/2 (0%) |
1/4 (25%) 2/4 (50%) 1/4 (25%) |
12/22 (55%) 6/22 (27%) 4/22 (18%) |
18/19 (95%) 1/19 (5%) 0/19 (0%) |
0.01 |
0 (0%) 1 (25%) 3 (75%) |
0 (0%) 0 (0%) 2 (100%) |
9 (47%) 7 (37%) 3 (16%) |
20 (100%) 0 (0%) 0 (0%) |
<0.0001 |
| IL6 (Log2) | 9.5 (9.1-10.7) | 9.1 (8.9-9.7) | 8.9 (8.6-9.3) | 8.1 (7.9-8.6) | 0.0006 | 9.3 (6.6-12.1) | 8.2 (7.4-8.9) | 5.9 (5.5-6.9) | 5.5 (5.1-6.2) | 0.01 |
| MCP-1 (Log2) | 11.1 (10.3-11.9) | 10.0 (9.2-12.1) | 9.7 (8.7-10.6) | 7.2 (6.6-7.8) | <0.0001 | 11.8 (11.2-12.5) | 13.3 (12.7-13.9) | 10.5 (9.6-11.2) | 10.0 (9.0-10.8) | 0.005 |
| NLR | 1.5 (1.1-16.1) | 4.3 (2.4-6.8) | 3.2 (2.0-5.6) n=29 | NA | 0.46 | 6.2 (3.0-16.0) | 6.4 (5.3-7.6) | 2.5 (1.9-4.7) | NA | 0.16 |
| MLR | 0.2 (0.1-0.6) | 0.3 (0.1-1.1) | 0.4 (0.2-0.8) n=29 | NA | 0.52 | 0.8 (0.5-2.3) | 0.2 (0.0-0.4) | 0.4 (0.2-0.6) | NA | 0.13 |
| Absolute neutrophil | 5.7 (2.6-11.9) | 5.8 (3.4-8.8) | 5.6 (3.7-9.5) n=29 | NA | 1.00 | 10.5 (5.0-16.9) | 0.5 (0.2-0.8) | 5.6 (4.1-7.4) | NA | 0.03 |
| Absolute lymphocyte | 2.0 (1.1-3.9) | 1.2 (0.9-2.3) | 1.8 (1.2-2.6) n=29 | NA | 0.56 | 1.6 (1.1-1.8) | 0.1 (0.0-0.1) | 2.1 (1.2-2.7) | NA | 0.03 |
| Absolute monocyte | 0.5 (0.4-0.6) | 0.4 (0.1-1.4) | 0.7 (0.5-1.1) n=29 | NA | 0.31 | 1.0 (0.6-3.5) | 0.0 (0.0-0.0) | 0.7 (0.6-0.9) | NA | 0.04 |
| RDW | 14.4 (12.0-17.3) | 12.9 (12.3-13.7) | 12.2 (11.7-13.0) n=31 | NA | 0.52 | 13.8 (13.4-14.0) | 14.4 (14.2-14.6) | 13.0 (11.9-13.9) | NA | 0.17 |
Data presented as n (%) or median (25th-75th percentile)
*
P-values for all 4 groups if available or the AP groups if NA for controls