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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Sep 23;41(11):2708–2725. doi: 10.1161/ATVBAHA.121.316615

Figure 4. Reduced adipose tissue expansion in Pcpe2−/− mice is independent of body weight.

Figure 4.

Male and female Ldlr−/− (control) and Ldlr−/− Pcpe2−/− (Pcpe2−/−) mice (10 weeks of age) were fed a high fat/high cholesterol (HFHC) diet for 25 weeks. At the end of the study, (A) body weights were measured and (B-D) VAT, SAT and BAT pads were removed and weighed. (E) Male and (G) female HFHC-fed mice were fasted for 4–5 hours and glucose tolerance tests were performed, with (H) area under the curve (AUC) calculated. All values represent the mean ± SD, n=11–15 male or female mice per genotype. Data were analyzed by ANOVA with Tukey’s multiple correction test.