Table 3.
Bone metastasis impact on the osteogenic niche in different primary tumors.
| Bone metastasis phenotype | Osteogenic niche interaction |
|||
|---|---|---|---|---|
| Early | Late | DTC survival | ||
| Renal Cancer | Osteolytic | Osteoblast inhibition + Osteocyte apoptosis | Osteoclast activation | Short term Unknown Long term |
| Prostate Cancer | Osteoblastic | Osteoblast activation + tumor cell osteomimicry + Osteoclast activation | Osteoclast activation | Short term and long term DTC survival |
| Breast Cancer | Osteolytic/Mixed | Osteoclast activation + osteoblast inhibition | Osteoclast activation | Short term and long term DTC survival |
| Lung Cancer | Osteolytic (non small-cell) Osteoblastic (small cell) |
Osteoclast activation | Osteoclast activation | Short term Unknown Long term |