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. 2021 Oct 6;24(11):103223. doi: 10.1016/j.isci.2021.103223

Figure 1.

Figure 1

STK39 is upregulated in CCA tissues and cell lines and is associated with poor prognosis

(A) The analysis of STK39 mRNA levels in 62 pairs of human CCA tissues and matched normal tissues.

(B) Analysis of STK39 expression in human CCA tissues and adjacent normal tissues in TCGA and GEO database.

(C) Pan-cancer analysis using TCGA data set showed that STK39 is mainly overexpressed in liver cancer (both CHOL and LIHC) and few other cancer types.

(D) STK39 mRNA and protein expression in one human intrahepatic biliary epithelial cell line (HiBEC) and four CCA cell lines were assessed by qRT-PCR and western blotting.

(E) The expression of STK39 in human HCC tissues (T) and matched normal tissues (N) were assessed by western blotting.

(F) Representative images of STK39 expression in CCA tissues by IHC staining, scale bar, 50μm.

(G) Elevated expression of STK39 was negatively correlated with the overall survival (OS) and disease-free survival (DFS) of patients with CCA. ∗p<0.05; ∗∗p<0.01; ∗∗∗p<0.001. Data were shown as mean ± SEM.