Table 1.

Pathophysiological functions of LysoPS receptors

Receptor	Experiment	Model or cell-types	Functions	Refs.
GPR34/LPS1	In vivo	DTH model	Suppress pro-inflammatory cytokine production	[43]
	In vivo	Fungal infection model	Promote fungal clearance	[43]
	In vivo	Neuropathic pain model	Enhance microglial pro-inflammatory responses	[46]
	In vitro	Primary microglia	Promote phagocytosis	[45]
	In vitro	Cervical cancer cell gastric cancer cell colorectal cancer cell	Promote cellular invasion and proliferation	[47, 48]
P2Y10/LPS2	In vitro	Primary dendritic cell, microglia	Suppress cytokine production	[7]
	In vitro	Primary eosinophil	Promote degranulation, survival, and formation of EET	[5, 8]
GPR174/LPS3	In vivo	EAE model sepsis model	Attenuate disease severity by suppressing Treg cell function	[3]
	In vivo in vitro	Primary CD4 T cell	Suppress IL-2 production	[6]
	In vivo	Splenic follicular B cell	Inhibit the cellular migration into the follicle center	[9]
	In vivo	Splenic marginal zone B cell	Inhibit the inflammatory responses, proliferation, and differentiation	[11, 4]