Cannabidiol has been shown to be effective in reduction of different seizure types, but no studies have evaluated the effect of cannabidiol on interictal epileptiform activity and sleep structures.

This prospective study showed that interictal epileptiform activity reduced significantly and sleep microstructure improved during cannabidiol treatment in children with drug-resistant epilepsy.

Based on the results of this study, it could be hypothesized that reductions in interictal epileptiform discharges and sleep improvement might contribute to potential positive effects of cannabidiol on cognitive functioning and behavior.