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. 2020 Nov 6;82(4):1030–1046. doi: 10.1007/s00248-020-01596-5

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© The Author(s) 2020, corrected publication 2020

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Fig. 1 — Principal coordinate analysis (PCoA) of samples based on the Bray-Curtis dissimilarity matrix. Each filled circle here represents a microbial community associated with non-tumor tissue (red), tumor tissue (blue), and saliva (green) with 95% confidence ellipses showing mean values of groups. A separation between groups was tested by comparing the principal coordinates using PERMANOVA statistical test (p value < 0.001). Further pairwise comparisons displayed significant differences in bacterial community composition among tumor and non-tumor (p = 0.00075) and saliva and tumor (p = 0.00075). Gaussian distribution of multivariate analysis of variance was tested to verify PERMANOVA assumptions (p value > 0.07)