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. 2021 Oct 27;10(10):72. doi: 10.1038/s41389-021-00361-8

Fig. 5. In vivo therapeutic efficacy of pharmacologic inhibitors of HIF-1α and Smad3 used alone or in combination in a single subtype model and a mixed glioblastoma model.

Fig. 5

A Kaplan–Meier survival curves for mice bearing a single subtype of tumor and mice bearing a mixed orthotopic tumor with PN12 and ME23 cells that were treated with 10 mg/kg GN44028, 7.5 mg/kg 2-BP, and 15 mg/kg (E)-SIS3 alone or in combination (n = 15 per group). Log-rank p-values were used to determine statistical significance. *p < 0.05. B Tumor weight in mice with a single subtype of tumor and mice with a mixed orthotopic tumor with PN12 and ME23 cells treated with 10 mg/kg GN44028, 7.5 mg/kg 2-BP, and 15 mg/kg (E)-SIS3 alone or in combination (n = 5 per group) after 6 weeks.