Fig. 8. RBM15 promotes tumor growth of HCC cells in vivo.

a, b Tumor xenograft models were constructed with stable RMB15-knockdown Huh7 cells (n = 5) and HCC-LM3 cells (n = 10). Tumor sizes were recorded per week consecutively to plot tumor growth curves. After collecting tumors from sacrificed mice, tumor weights were measured and compared between shRBM15 and shNC cells (*p < 0.05, **p < 0.01, ***p < 0.001; two-way ANOVA and t test); c representative IHC staining images of xenograft tumors. Knockdown of RBM15 decreased the expression of YES1, PCNA, and Ki-67 (scale bars, 200 μm); the data are presented as mean ± SD; d abstract graph illustrated our findings on RBM15-mediated m⁶A regulation. The data are presented as mean ± SD.