Table 1.

Bacterial relative abundances in normal and tumor-adjacent-normal tissue.

Genus	Median log2 RA Cancer	Median log2 RA Healthy	Effect size	P value	Padj
Corynebacterium	−3.05078	0.55456	0.93460	0.00002	0.00024
Acinetobacter	3.52399	4.99866	0.89468	0.00004	0.00047
Prevotella	−0.07806	2.23876	0.83597	0.00010	0.00085
Gammaproteobacteria (unclassified)	−3.41404	0.24559	0.83370	0.00022	0.00147
Prevotella	−2.19046	0.61126	0.83049	0.00048	0.00297
Lactococcus	1.80420	3.84987	0.74354	0.00003	0.00038
Lactococcus	1.21785	3.44230	0.72191	0.00041	0.00267
Prevotella	−3.88765	−1.18212	0.67504	0.00204	0.00919
Lactococcus	−0.23240	3.06471	0.56543	0.00320	0.01553
Prevotella	−3.43107	−1.36356	0.49660	0.03067	0.08866
Streptococcus	−0.77006	1.46508	0.42017	0.04131	0.12656
Micrococcus	0.52029	1.11744	0.36611	0.03150	0.09472
Staphylococcus	−1.35312	−3.22940	−0.44771	0.03066	0.08570
Staphylococcus	2.57149	1.37032	−0.45353	0.03536	0.11197
Lactobacillus	2.73155	1.64036	−0.47398	0.02433	0.08437
Propionibacterium	4.31073	3.43269	−0.48797	0.03016	0.10008
Bacillus	−2.22084	−4.77999	−0.51615	0.02394	0.06333
Bacillales (unclassified)	−1.45938	−4.20697	−0.51839	0.01784	0.05692
Bacillus	−2.39633	−5.17174	−0.55899	0.01690	0.05183
Staphylococcus	1.32550	−1.53964	−0.66019	0.00057	0.00348
Bacillus	1.14347	−2.40476	−0.79326	0.00020	0.00140
Gammaproteobacteria (unclassified)	0.05306	−3.91697	−0.98396	0.00002	0.00020
Bacillus	4.56707	0.08631	−1.32125	0.00000	0.00000

Median log2 relative abundances (RA) and effect sizes of different genera in healthy-normal tissue and tumor-adjacent-normal tissue. Negative effect size value indicates a higher relative abundance of genera in tumor-adjacent-normal tissue compared to healthy-normal tissue.

Bolded values indicate bacterial genera found to significantly differ between the study groups after adjusting for multiple testing.