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Gene targeting of Nkx2.6. (A) The Nkx2.6 genomic locus and the structure of the targeting vector are shown. Homologous recombination resulted in the replacement of the second exon, which encodes the homeodomain and the NK-2-specific domain. Spe, SpeI; Xb, XbaI; Sal, SalI. (B) Genotyping of ES cell clones. Genomic DNA was digested with SpeI and analyzed by Southern blotting using the 5′ probe (SpeI-XbaI fragment).
