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. 2021 Oct 27;11:21206. doi: 10.1038/s41598-021-00483-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of the label-free quantification approach. (A) Volcano plot depicts differential expression between two craniopharyngioma subtypes (ACP and PCP) using label-free quantification data. (B) Principal component analysis of the 11-tumor label-free proteomic data. (C) The heatmap represents unsupervised hierarchical clustering of the 11 tumor samples using 923 proteins that were differentially expressed as identified by label-free quantification. (D) Gene ontology (GO) enrichment analysis of the label-free data. The red points indicate upregulated proteins in ACPs, and blue points indicate upregulated proteins in PCPs.