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. 2021 Oct 27;12(11):1010. doi: 10.1038/s41419-021-04204-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The serum GOT and GPT were measured for the mice treated with CCL₄ + PBS, CCL₄ + HepG2-EVs, or CCL₄ + PXB-EVs. B HE staining and C TUNEL staining of liver sections of the mice treated with CCL₄ + PBS, CCL₄ + HepG2-EVs, or CCL₄ + PXB-EVs. B Areas of necrotic area (NA) were calculated in 5 fields from 3 mice. C TUNEL positive apoptotic cells (green) and DAPI positive nuclei (blue) are illustrated. TUNEL positive cells were enumerated in 10 fields from 3 mice. Ratio to total cells was calculated. Statistical analysis was performed using one-way ANOVA and subsequent Tukey’s HSD method. *P < 0.05, **P < 0.01. Black and white bars indicate 50 μm.