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. 2021 Oct 27;12(11):1010. doi: 10.1038/s41419-021-04204-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A CCR2, CCR8, and CCR9 mRNAs in BM cells 12 h after HepG2-EVs or PXB-EVs addition into culture supernatant were measured via real-time (RT-qPCR), and each sample was normalized relative to β-actin expression. Data represent the mean ± SD of triplicate experiments. B CCR2, CCR8, and CCR9 mRNA in BM cells collected from mice 48 h after injection of CCL₄ + PBS or CCL₄ + PXB-EVs were quantified using RT-qPCR. β-actin was used as an internal control. Data represent the mean ± SD of triplicate experiments. Statistical analysis was performed using one-way ANOVA and subsequent Tukey’s HSD method or student’s t test. *P < 0.05, **P < 0.01.