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. 2021 Oct 27;11:21179. doi: 10.1038/s41598-021-00654-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo metabolism study in minipig. (a) Time profiles in minipig after dosing (i.v., 50 nmol/kg) of analogue 1 with fatty acid moiety on N-terminus and (b) analogue 28 with fatty acid moiety in position 30. Time profiles of identified degradation products are also shown (dotted lines). The LC-MS response was calculated from peak integration of the most abundant charge state.