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. 2021 Oct 27;4:1228. doi: 10.1038/s42003-021-02658-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Cumulative Distribution Functions (CDF) are plotted for FRET efficiency traces obtained from at least (n = 20) HIV-1 HXB2 V4-GFP_OPT virions in presence of living T cells without (solid dots) or with (solid triangles) neutralizing antibodies PGT145 (a), b12 (b), and 10E8 (c). Each FRET regime (high, E_app>0.23 in red; intermediate, 0.12<E_app<0.23, in green; low_, E_app<0.12, in blue) determines the Env conformational state/distribution and kinetics. d The HIV-1 Env structures representing closed Env associated with PGT145 (PBD ID 6NIJ, left), b12 (PBD ID 5VN8, middle) or 10E8 (PBD ID 5VN3, right) were modified to illustrate the labelling of the V4 loop with GFP_OPT.