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. 2021 Oct 27;11:21227. doi: 10.1038/s41598-021-00691-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The potential association of Mx2 with oHSV-1 resistance in other human tumor cell lines. (A) The mRNA accumulation of Mx2 in other human tumor cell lines. RQ: relative quantity, values were compared with Mx2 mRNA levels in A172 cells. (B) Virus yields in Mx2-depleted D54, DU145, WIDR, SCC9, LAMP, 5637 and U138. Mx2 was knockdown in above human tumor cells lines by siRNA transfection. Treated cells were exposed to 0.1 MOI T1012G, virus progeny was harvested at the 24 h post-infection and titrated in Vero cells. (C) Investigation of Mx2 knockdown efficiency by RT-qPCR assay. (D,E) The cell viability of Mx2-depleted A172 cells and WIDR cells. Mx2-depleted and mock-depleted A172 cells or WIDR cells were infected with oHSV-1 T1012G at an MOI of 0.01, 0.1 MOI, and cell viability was analyzed every 24 h over a time course of 72 h with CCK-8 Assays Kit.