Table 2.
Cytokine Levels over Course of RBC Treatment – Percent change per additional transfusion* (N=71)
| Cytokine | % change ± SE, per cumul transfusion | p | Holm-Adjusted p | FDR |
|---|---|---|---|---|
| IL-8 | 9.5 ± 1.8 | <0.0001 | 0.0000 | 0.0000 |
| sICAM-1 | 8.1 ± 1.7 | <0.0001 | 0.0000 | 0.0000 |
| TNF-β | 7.5 ± 1.6 | <0.0001 | 0.0000 | 0.0000 |
| IL-6 | 12.9 ± 3.3 | <0.0001 | 0.0004 | 0.0001 |
| IP-10 | 7.4 ± 2.4 | 0.001 | 0.0168 | 0.0043 |
| IL-18 | 4.6 ± 1.7 | 0.005 | 0.0635 | 0.0144 |
| TPO | 3.8 ± 1.4 | 0.007 | 0.0853 | 0.0178 |
| MCP-1 | 4.9 ± 1.9 | 0.007 | 0.0893 | 0.0177 |
| IFN-ϒ | 8.1 ± 4.1 | 0.03 | 0.3798 | 0.0729 |
| IL-10 | 3.8 ± 2.2 | 0.08 | 0.7860 | 0.1493 |
| IL-2 | 4.8 ± 3.2 | 0.12 | 1.0000 | 0.2052 |
| TNF-α | 1.8 ± 1.3 | 0.16 | 1.0000 | 0.2467 |
| sVCAM-1 | 1.0 ± 0.8 | 0.21 | 1.0000 | 0.3111 |
| VEGF | 1.7 ± 2.0 | 0.38 | 1.0000 | 0.5151 |
| IL-1β | 4.0 ± 5.9 | 0.48 | 1.0000 | 0.6065 |
| IL-13 | −3.4 ± 7.4 | 0.64 | 1.0000 | 0.7619 |
| IL-4 | −1.1 ± 5.1 | 0.83 | 1.0000 | 0.9282 |
| IL-12 | −0.2 ± 3.0 | 0.95 | 1.0000 | 0.9977 |
| IL-17 | 0.0 ± 2.2 | 0.99 | 0.9871 | 0.9871 |
Adjusted for Sex, Gestational Age (GA) at birth, Birth Weight, Age, and pre-transfusion hemoglobin (ptHb)
In Order of Significance with Holm Step-Down Adjustment; Maximum Experimentwise Error Rate = 0.05; FDR = false discovery rate
Abbreviations in alphabetical order:
interleukin-1 beta (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-13 (IL-13), interleukin-17 (IL-17), interleukin-18 (IL-18), interferon gamma-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), interferon gamma (IFN-ϒ), tumor necrosis factor alpha (TNF-α), tumor necrosis factor beta (TNF-β), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and vascular endothelial growth factor (VEGF), and thrombopoietin (TPO)