Table 3.
Cytokine Levels over Course of RBC Treatment – Percent change per additional transfusion—Sex Interactions* (N=71)
| Cytokine | % change ± SE, per cumul transfusion (p) | M (p) | F (p) | p|M=F | Holm-Adjusted p | FDR |
|---|---|---|---|---|---|---|
| MCP-1 | 4.9 ± 1.9 (p=0.007) | −0.8 ± 2.4 (p=0.73) | 8.9 ± 2.6 (p=0.0004) | 0.004 | 0.0360 | 0.0360 |
| IP-10 | 7.4 ± 2.4 (p=0.001) | 1.0 ± 3.3 (p=0.75) | 11.9 ± 3.2 (p<0.0001) | 0.014 | 0.1120 | 0.0630 |
| IL-6 | 12.9 ± 3.3 (p<0.0001) | 5.2 ± 4.0 (p=0.17) | 18.4 ± 4.6 (p<0.0001) | 0.02 | 0.1400 | 0.0600 |
| TNF-β | 7.5 ± 1.6 (p<0.0001) | 10.0 ± 2.2 (p<0.0001) | 5.8 ± 2.2 (p=0.006) | 0.15 | 0.9000 | 0.3375 |
| IL-18 | 4.6 ± 1.7 (p=0.005) | 4.0 ± 2.3 (p=0.08) | 5.0 ± 2.2 (p=0.02) | 0.76 | 1.0000 | 1.0000 |
| IL-8 | 9.5 ± 1.8 (p<0.0001) | 9.1 ± 2.4 (p<0.0001) | 9.7 ± 2.4 (p<0.0001) | 0.84 | 1.0000 | 1.0000 |
| TPO | 3.8 ± 1.4 (p=0.007) | 3.5 ± 2.0 (p=0.07) | 4.0 ± 1.9 (p=0.03) | 0.86 | 1.0000 | 1.0000 |
| sICAM-1 | 8.1 ± 1.7 (p<0.0001) | 7.8 ± 2.3 (p=0.0005) | 8.3 ± 2.3 (p=0.0001) | 0.88 | 1.0000 | 0.9900 |
| IFN-ϒ | 8.1 ± 4.1 (p=0.03) | 7.9 ± 5.6 (p=0.13) | 8.2 ± 5.4 (p=0.11) | 0.97 | 0.9700 | 0.9700 |
Adjusted for Gestational Age (GA) at birth, Birth Weight, Age, and pre-transfusion hemoglobin (ptHb) In Order of Significance with Holm Step-Down Adjustment; Maximum Experimentwise Error Rate = 0.05; FDR = false discovery rate
Abbreviations in alphabetical order:
interleukin-1 beta (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-13 (IL-13), interleukin-17 (IL-17), interleukin-18 (IL-18), interferon gamma-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), interferon gamma (IFN-ϒ), tumor necrosis factor alpha (TNF-α), tumor necrosis factor beta (TNF-β), soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and vascular endothelial growth factor (VEGF), and thrombopoietin (TPO)