Skip to main content
. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2021 Apr 28;126:71–78. doi: 10.1016/j.semcdb.2021.04.012

Figure 1. Changes to the core molecular clock control mammalian circadian period.

Figure 1.

(A) Simplified schematic of the core mammalian feedback loop mediated by CLOCK:BMAL1 expression of CRY and PER genes with an auxiliary loop that consists of the retinoic acid receptor-related orphan receptor α (RORα) and the nuclear receptors REV-ERBα/β. (B) Functional domain architecture of core clock proteins with structured domains (boxes) and traces indicating the propensity for intrinsic disorder [92]: bHLH, basic helix-loop-helix; PAS, PER-ARNT-SIM; TAD, transactivation domain; Ac, acetyl-CoA binding, Q-rich, polyglutamine; CC, coiled-coil; CKBD, Casein Kinase 1-binding domain; and CBD, CRY-binding domain with residue numbering underneath. (C) Period effects from select mammalian clock alleles of core clock proteins.