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. 2021 Oct 27;12(11):1009. doi: 10.1038/s41419-021-04284-5

Fig. 5. Fer-1 treatment attenuates IMQ-induced psoriasis-like dermatitis of mice.

Fig. 5

Mice were topical administered 5 mg IMQ cream or control cream on mouse ears for 7 consecutive days. An equal volume of Fer-1 (0.8 mg/kg/day) or 10% DMSO (50 μl) were painted on mouse ears 30 min before IMQ application. A Schematic representation of the animal experiments for the Control, IMQ, and IMQ + Fer-1 groups (n = 5). B Gross photograph of ears at day 8. C Ear thickness on day 8. D Hematoxylin and eosin staining of ear sections on day 8. Scale bar, 100 μm. E The thickness of the epidermis in ear sections was calculated using ImageJ software. Values were presented as the mean ± standard error (n = 5). ***p < 0.001. Independent experiments were repeated three times. IMQ imiquimod, Fer-1 ferrostatin-1.