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. 2021 Oct 27;12(11):1008. doi: 10.1038/s41419-021-04319-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Total traveled distance and b the number of rearings were performed in open-field tests (N = 6–31 mice per genotype). Unpaired t-test, *p = 0.0471 (total distance at 11 months of the age); Mann–Whitney test, **p = 0.0011 (total distance at 15 months old); and **p = 0.0011 (rearings at 15 months old). c The latency to fall from rotarod for 6-, 11-, and 15-month-old Pitx3^cWT and Pitx3^cKO mice (N = 6–27 mice per genotype). Unpaired t-test, *p = 0.0107 (11 months old); and *p = 0.0206 (15 months old). d The turning time and total task time for 6-, 11-, and 15-month-old Pitx3^cWT and Pitx3^cKO mice in pole tests (N = 6–27 mice per genotype). Unpaired t-test, ****p < 0.0001 (turning time at 15 months old); and ****p < 0.0001 (total time at 15 months old); Mann–Whitney test, *p = 0.016 (turning time at 11 months old).